Technology Information  Title Nonoxynol-9-alpha-Cyclodextrin Inclusion Compound and Its Application for the Controlled Release of Nonoxynol-9 Spermicide Manager Billy Houghteling Case Number 07088 Abstract An inclusion compound between nonoxynol-9 (N-9) and a-cyclodextrin (CD) was successfully developed. Testing of silicone elastomer embedded with a small amount of the inclusion complex (N-9-a-CD-IC) against bovine sperm was successful for the controlled release of N-9 and resulted in sperm cell destruction. The inventors examined adding silicone elastomer network to neat N-9 and embedding silicone elastomer network in N-9-a-CD-IC crystals where N-9 concentration was equal in quantity. They observed that for formulations have similar efficiency in killing bovine sperm cells. The reported invention may prove to be an alternative for commercially available non-latex condoms featuring controlled release of spermicide. The new improved N-9 (which is made by embedding silicone network into N-9-a-CD-IC crystal) has several advantages over currently available products. These advantages include: 1) It provides more convenient and permanent delivery. 2) It has an extended shell life. 3) It has less potential for human contact. About the Inventors: Dr. Hyun Suk Whang Dr. Whang holds Ph. D. in Fiber and Polymer Science Program from the College of Textiles, North Carolina State University and is the primary inventor on the technology described above. She is currently working as a research faculty member in the Fiber and Polymer Science Program in the College of Textiles at North Carolina State University. She is dynamic, diligent, enthusiastic, supervising undergraduate (faculty mentor for Summer 2007 Undergraduate Research Award) and graduate students, writing proposals, initiating research funds, and pursuing valuable research in her field of expertise. One of her areas of expertise is in the delivery of various additives(antimicrobial agent, insect repellent, antioxidant, fragrance, spermicide, etc.) which aids in controlled release of the additives into various polymer materials by making cyclodextrin inclusion complexes. In the present scenario they have great potential applications in the consumer market. Dr. Alan Tonelli- Professor Tonelli's research interests include the conformations, configurations, and structures of synthetic and biological polymers, their determination by NMR, and establishing their effects on the physical properties of polymers. Dr. Tonelli holds a B.S. in Chemical Engineering from the University of Kansas in 1964 and a Ph.D. in Polymer Chemistry from Stanford University, where he was associated with the late Professor Paul J. Flory. He was a member of the Polymer Chemistry Research Department at AT&T Bell Laboratories, Murry Hill, N.J. for 23 years, and in 1991 joined the Fiber and Polymer Science Program in the College of Textiles at North Carolina State University in Raleigh. Technology inquiries should be directed to: Mr. Billy B. Houghteling Director Office of Technology Transfer (919) 515-7199 billy_houghteling@ncsu.edu Taxonomy NCSU Technology Categories/Materials NCSU Technology Categories/Textiles Keywords Inclusion Compounds, Contraceptive  Attachments  Description Size Download J. Applied Polymer Science Publication (2007) 230194 Download Request Information If you are a registered user, please login before requesting information by clicking the Login button. If you have not registered, click the Login button for registration information.